Updating on the pathogenesis of systemic lupus erythematosus


Physicians have commonly relied on the American College of Rheumatology (ACR) Criteria for the classification of SLE.

These criteria were preliminarily developed in 1971, revised in 1982, and updated in 1997 [].

Systemic lupus erythematosus is an autoimmune disease which afflicts many systems.

updating on the pathogenesis of systemic lupus erythematosus-48updating on the pathogenesis of systemic lupus erythematosus-26updating on the pathogenesis of systemic lupus erythematosus-35

This loss of tolerance becomes clinically detectable by the presence of antinuclear antibodies.SLE is a chronic autoimmune disease that can affect almost any organ system; thus, its presentation and course are highly variable, ranging from indolent to fulminant.In childhood-onset SLE, there are several clinical symptoms more commonly found than in adults, including malar rash, ulcers/mucocutaneous involvement, renal involvement, proteinuria, urinary cellular casts, seizures, thrombocytopenia, hemolytic anemia, fever, and lymphadenopathy.The intrarenal etiology of lupus nephritis involves antibody binding to multiple intrarenal autoantigens rather than the deposition of circulating immune complexes.Tertiary lymphoid tissue formation and local antibody production add to intrarenal complement activation as renal immunopathology progresses.Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE.

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